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天然药物化学教研室现有教师15人,其中教授1名, 副教授5名,讲师9名。学历结构:博士5名,在读博士1名,硕士9名。 
[科研方向]
      天然药物(中药)活性成分的提取、分离、鉴定;
肺动脉高压机制及治疗药物研究;生物活性新物质的合成与探索,绿色合成策略用于药物及手性药物的合成研究,以及对天然化合物进行的分子结构修饰与活性优化。

[承担课题]

课题来源

项目名称

编号

省自然科学基金

东北苍耳的抗癌活性研究

LC2009C12

省中医药管理局项目

大庆地区防风的质量标准研究

zhy10-w53

省卫生厅科技项目

血经草的HPLC指纹图谱研究

2007-491 

省卫生厅科技项目

大庆地区马齿苋质量标准研究

2012-782

哈医大大庆校区种子基金

ClC-3在15-HETE介导的HPV血管重构中的作用

DQ201201

省教育厅课题

ClC-3在15-HETE介导的HPV血管重构中的作用及机制


省卫生厅科技项目

三氧化二砷在治疗肺动脉高压中的作用及其机制研究

2012-781

省高等教育学会“十二五”规划课题

创建中药专业创新型人才培养模式的研究

HGJXH B2110712

省高等教育学会“十二五”规划课题

新时代背景下药学生教学模式改革新策略

HGJXH 

C110733

省高等教育学会“十二五”规划课题

药学生自主学习和实验意识的培养与研究

HGJXH 

C110734

哈医大大庆校区种子基金

相转移催化羰基αC-H键绿色氧化羟基化的研究

DQ201303

省教育科学“十四五”规划重点课题新医科背景下《天然药物化学》混合式教学模式研究与实践GJB1421261
省教育科学“十四五”规划重点课题基于SCL的小讲课优化翻转课堂在药物化学理论教学中的应用研究GJB1421262


[论文著作

1.Yuhua Bai, Ping Lu, Chenghua Han, Chunyue Yu, Minggang Chen, Fa He, Dan Yi, Lijun Wu. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery, Molecules 2012, 17, 14918-14927. 

2.Fa He , Yuhua Bai , Jing Wang , Jing Wei, ChunYue Yu, Sen Li, Weili Yang and Chenghua Han. Isolation and Purification of Oridonin from the Whole Plant of Isodon rubescens by High-Speed Counter-Current ChromatographyMolecules 2011, 16(9), 7949-7957.

3.Yuhua Bai, Ming Zhao; Liming Bai; Ryo Hasegawa; Jun-ichi Sakai; Toshiaki Hasegawa; Tomokazu Mitsui; Hirotsugu Ogra; Takao Kataoka; Katsutoshi Hirose; Masayoshi Ando .The biological activities of cardenolide triglycosides from stems and twigs, and leaves of Nerium oleander Journal of Wood Science.2011, 57(1) : 56-65.

4.Ming Zhao, Liming Bai, Asami Toki, Ryo Hasegawa, Jun-ichi Sakai, Toshiaki Hasegawa, Tomokazu Mitsui, Hirotsugu Ogura, Takao Kataoka, Yuhua Bai, Mariko Ando, Katsutoshi Hirose and Masayoshi AndoThe Structure of A New Cardenolide Diglycoside and the Biological Activities of Eleven Cardenolide Diglycosides from Nerium oleanderChemical & Pharmaceutical Bulletin201159(3):371-7

5.Liming Bai, Ming Zhao, Asami Toki, Toshiaki Hasegawa, Jun-ichi Sakai, Xiao-yang Yang, Yuhua Bai, Hirotsugu Ogura, Tomokazu Mitsui and Takao Kataoka, et al.Polar cardenolide monoglycosides from stems and twigs of Nerium oleander and their biological activities Journal of Wood Science. 2011, 57(1) :47-55.

6.Liming Bai, Ming Zhao, Asami Toki, Jun-ichi Sakai, Xiao-yang Yang, Yuhua Bai, Mariko ANDO,f Katsutoshi HIROSE,g and Masayoshi ANDO. Three New Cardenolides from Methanol Extract of Stems and Twigs of Nerium oleander , Chemical & Pharmaceutical Bulletin ,2010,58(8):1088-1092

7.LIMING BAI, TOSHIAKI HASEGAWA, JIAO BA,MUTUMI KITABATAKE, JINLAN WANG, JUNICHI MATUBARA, JUN-ICHI SAKA,JUNGUI DAI, SHUJUN ZHANG, WANXIA TANG, LIYAN WANG, YUHUA BAI et al., Synthesis and Structure-ActivityRelationships of Some Taxoids as Multidrug Resistance Modulator in MDR Cancer Cells, 收编于国际专著Compendium of Bioactive Natural Products,Studium Press LLC, USA,2009-10. 

8.Liming Bai, Liyan Wang, Liwei Fu, Ming Zhao, Shujun Zhang,,Saori Kakuta, Junichi Sakai, Wanxia Tang, Yuhua Bai et al., Oleanane-, ursane-, lupane-, and taraxasterane-type pentacyclic triterpenes isolated from the medicinal plants Nerium oleander, Ixeris chinensis, Sonchus oleraceus and Phytolacca americana. Cytotoxicity studies on human cancer cell lines, and MDR cancer reversal and anti-inflammatory activities, 收编于国际专Pentacyclic Triterpene as a promising Agents in Cance, NOVA SCIENCE PUBULISHER INC. Hauppauge, NY, 2009-10.

9.Liyan Wang, Liming Bai, Daiske Tokunaga, Yuusuke Watanabe, Toshiaki Hasegawa, Junichi Sakai, Wanxia Tang, Yuhua Bai, Katsutoshi Hirose, Takao Yamori, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando.The polar neutral and basic taxoids isolated from needles and twigs of taxus cuspidata and their biological activity, Journal of Wood Science.2008, 54 (5), 390-401

10.Liyan WangLiming BaiDaisuke TokunagaYuusuke WatanabeJun-ichi Sakai,Wanxia TangYuhua Bai.et alTwo New Taxoids from the Needles and Young Stems of Taxus cuspidataHETEROCYCLES2008,75,(4):911-917

11.Liyan Wang Liming BaiToshiaki HasegawaXiaoyang YangYuhua Bai et al Bioactive Triterpene Saponins from the roots of Phytolacca Americana  JOURNAL OF NATURAL PRODUTS.2008 ,71,(1):35-40SCI

12. Li Y, Li Q, Wang Z, Liang D, Liang S, Tang X, Guo L, Zhang R, Zhu D.15-HETE suppresses K+ channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells. Apoptosis. 2009;14(1):42-51.

13. Li Yumei, Kumazawa Toshihiko, Ishiguro Tsukasa, Kawakami Yuriko, Nishitani Hiromi, Tagawa Yoshiaki, Matsumoto Yukiharu. Congenit Anom (Kyoto). Hypothyroidism caused by phenobarbital affects patterns of estrous cyclicity in rats. 2011;51(2):55-61.

14.Yao L, Lu P, Li Y, Yang L, Feng H, Huang Y, Zhang D, Chen J, Zhu D. Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats. Eur J Pharmacol. 2012 Dec 7.

15.Zhang L, Wu Y, Li Y, Xu C, Li X, Zhu D, Zhang Y, Xing S, Wang H, Zhang Z, Shan H. Tanshinone IIA Improves miR-133 Expression Through MAPK ERK1/2 Pathway in Hypoxic Cardiac Myocytes. Cell Physiol Biochem. 2012;30(4):843-852.

16.Wang Z, Tang X, Li Y, Leu C, Guo L, Zheng X, Zhu D. 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells.Eur J Pharmacol. 2008;588(1):9-17.

17.Guo L, Tang X, Chu X, Sun L, Zhang L, Qiu Z, Chen S, Li Y, Zheng X, Zhu D. Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction. Prostaglandins Leukot Essent Fatty Acids. 2009; 80(2-3):115-23.

18.Mingming Lian, Zhi Li, Yuanchun Cai, Qingwei Meng and Zhanxian Gao, Enantioselective Oxidation of β-keto Esters by Molecular Oxygen, Catalyzed by Chiral Phase-Transfer Catalyst, Chemistry - An Asian Journal, 2012, 7, 2019-2023

19.Mingming Lian, Zhi Li, Jian Du, Qingwei Meng and Zhanxian Gao, Asymmetric Direct α-Hydroxylation of β-Oxo Esters by Phase-Transfer Catalysis Using Chiral Quaternary Ammonium Salts, European Journal of Organic Chemistry, 2010, 34, 6525-6530

20.Hongjie Yao, Mingming Lian, Zhi Li, Yakun Wang, and Qingwei Meng, Asymmetric Direct α Hydroxylation of β Oxo Esters Catalyzed by Chiral Quaternary Ammonium Salts Derived from Cinchona Alkaloids, The Journal of Organic Chemistry,2012, 77, 9601 − 9608

21.Yuanchun Cai, Mingming Lian, Zhi Li, Qingwei Meng, Enantioselective a -hydroxylation of b -keto esters catalyzed by chiral S-timolol derivatives, Tetrahedron 2012, 38, 7973-7977

22.Daoping Cui, Yueqing Li, Mingming Lian, Feng Yangb and Qingwei Meng, Development of a simple and stability-indicating RP-HPLC method for determining olanzapine and related impurities generated in the preparative process, Analyst, 2011, 3149-3156

23.Bin Gong, Qingwei Meng, Tian Su, Mingming Lian, Qing Wang, Zhanxian Gao Lappaconitine-Catalyzed Asymmetric α-Hydroxylation of β-Keto Esters: A Brønsted Base Organocatalyst Developed from Terpenoid Alkaloids, Synlett, 2009, 2659

24.白玉华,孙颖,于春月等.榛花挥发油化学成分.药学与临床研究,2010,18(3):265-266

25.白玉华,王晶,孙颖等.冬凌草挥发油的GC-MS分析.药学与临床研究,20095):370-372

26.白玉华,安東正義.日本苦苣菜的化学成分.中国药科大学学报,200839:279-281

27.白玉华,于辉,孙世芹等.日本苦苣菜化学成分研究.药学与临床研究.20086):444-446

28.于春月,张特立,刘新华,.血经草总黄酮的提取工艺研究.中国医药导报,2011, 8(8): 60-61

29.于春月,张特立,白玉华,.大庆市不同产地防风中有效成分含量比较.中国医药导报,2011,8(34):39-41

30.陈明刚,刘艳瑞,张良栓,.卫矛总黄酮滴丸制备工艺研究.哈尔滨医科大学学报,2012, 3(46):241-243

31.韩成花,罗惠善,徐东花.平贝母氯仿和乙酸乙酯提取物化学成分的研究.黑龙江中医药, 2008,37(3):47-48

32.韩成花,罗善顺,白玉华,.药学生实验意识的培养.中国医药导报,2011,8(8):116-117


[申请专利]

丙基胺乙基硫代磷酸高纯稳定晶体及其制备方法。专利号: CN101412732

高乌甲素作为催化剂制备手性α-羟基-β-二羰基化合物的方法。专利号: CN101503358


[教学任务]
本科生:《中药化学》《天然药物化学》《中药分析》《有机化合物波谱解析》《药物化学》
专科生:《天然药物化学》《药物化学》《药物分析基础及应用》《药物分析》 

[教材编写]
《药品经营质量管理规范(GSP)实用教程》 
《药物分析基础及应用》 
《市场营销》 
《药物分析基础及应用》 
《药物化学》

《药物分析实验教材》

《药物合成反应》

《天然药物化学实验》

《药物化学实验》 

 


地址:黑龙江省大庆市高新区新阳路 39 邮政编码:163319
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版权所有:哈尔滨医科大学大庆校区
地址:黑龙江省大庆市高新区新阳路39
黑ICP备2021002235号-1