国家级项目
1)题目:线粒体融合蛋白1/2(Mfn1/2)在缺氧肺血管稳态失衡、重构中的作用及分子机制。 课题编号:91339107,金额:100万元。
2)题目:15-PGDH/15-KETE在缺氧性肺血管内皮细胞增殖,血管新生中的作用及机制的研究。课题编号:81270113,金额:110万元。
3)题目:HO-1在15-LO调控的缺氧肺动脉高压中的作用及机制研究。课题编号:331071007,金额:33万元。
4)题目:缺氧对15-脂氧酶的调控作用及分子机制。课题编号:20112307110022,金额:12万元。
5)题目:KATP通道的谷胱甘肽化作为败血症严重性的标记作用临床前研究。课题编号:81300192,金额:23万元。
6)题目:HL效灵止痛胶囊临床前研究。课题编号:2009GJB20046,金额:40万元。
7)题目:抗体修饰的miR-21脂质体靶向急性缺血心肌的研究 。课题编号:81402865,金额:23万元。
8)题目:多肽纳米级缓释胶囊免疫耐受治疗实验性中枢神经。课题编号:30370508。
9)题目:国家十五科技攻关项目“常用中药材化学成分及有效成分—垂盆草子的研究”(2000-2003)。
10)题目:国家“十五”科技攻关引导项目(2004BA754C):骨髓基质干细胞治疗神经性自身免疫性疾病的实验研究(课题参加人)。
省级项目
1)题目:抗cTnI抗体修饰隐形脂质体心肌靶向性的研究。 课题编号:D201043,金额:5万元。
2)题目:基于多孔壳/膨胀核的聚合物复合微球为载体的脉冲载药体系的研究。课题编号:QC2001C099,金额:5万元。
3)题目:喜树毛状要培养体系构建及产物分析。课题编号:C2007-01,金额:3万元。
4)题目:苏木乙酸乙酯提取物中免疫掏活性成分筛选及其作用。课题编号:LRB06-335,金额:2万元。
5)题目:东北苍耳抗癌活性成分研究。课题编号:LC2009C12,金额:5万元。
6)题目:RNAi技术结合纳米给药系统治疗大鼠心率失常的研究。课题编号:LRB08313,金额:5万元。
7)题目:环境因子对喜树毛状根生长和喜树碱合成的影响。 课题编号:11511178
8)题目:槲寄生自乳化软胶囊的研究。课题编号:QC2001C099,金额:5万元。
9)题目:抗菌肽SMAP-29衍生物的克隆表达及活性研究。课题编号:2006-360。
10)题目:羧酸酯酶-2作为肝脏恶性肿瘤早期诊断的分子标志物的免疫试剂盒研制。
11)题目:羧酸酯酶-2在肝脏恶性肿瘤早期诊断中的作用及应用研究。
12)题目:伏立康唑纳米缓释颗粒的研制及疗效分析。
13)题目:新型脑靶向性脂质体的分布与控制。
14)题目:无机粒子修饰的阿司匹林及抗胃黏膜损伤研究。
15)题目:黄芪甲苷分子印迹聚合物微球的制备及黄芪甲苷分离研究。
16)题目:黄芪甲苷分子印迹聚合物微球的制备及黄芪甲苷分离研究。
17)题目:基于多孔壳/膨胀核的聚合物复合微球为载体的脉冲载药体系的研究。
18)题目:HSYA降低缺氧肺动脉高压的作用机制研究。
19)题目:土壤肥力综合评价与赤芍有效成分芍药苷含量的研究。省卫生厅。金额:0.5万。
20)题目:血经草HPLC指纹图谱研究。
21)题目:CIC-3在15-HETE介导的HPV血管重构中的作用及机制。
22)题目:加味附桂地黄胶囊制剂工艺优化研究。
23)题目:布地奈德菌群触发型结肠靶向片的研究。
24)题目:牛蒡子降血糖活性成分研究 2011省卫生厅。
25)题目:柿霜PPA粉双层缓释口腔贴膜的制备工艺及质量评价研究。
26)题目:表皮生长因子脂质体透皮贴剂的研究。
27)题目:黄芪苷抗非甾体抗炎药导致的胃粘膜损伤的作用及机理研究。
28)题目:芍药炮制前后多成分的变化规律。
29)题目:大庆地区马齿苋质量标准研究。
30)题目:中药薤白抗缺氧性肺动脉高压的作用及机制研究。
31)题目:纳米生物活性玻璃缓控释贴剂的研究。
32)题目:基于代谢组学方法寻找特异性皮炎患者血清中的标志物。
33)题目:虎杖苷治疗肺动脉高压机制的研究。
大庆市项目
1)题目:大庆生物医药研发平台。 课题编号:scx2010-11,金额:200万元。
2)题目:中药现代化研究中心平台。课题编号:DQGX09NL001,金额:5万元。
3)题目:颈松喷雾剂临床前研究。课题编号:DQGX08YF026,金额:8万元。
4)题目:心肌靶向制剂治疗心率失常的研究。课题编号:ZHY10-Z101,金额:6万元。
5)题目:大庆地产黄芩土壤营养与有效成分相关性的实验研究。大庆市科学技术计划项目。金额:3.6万。
6)题目:中药红花抗肺动脉高压作用及其机制研究。
7)题目:肾复康胶囊的研制。
8)题目:具有双峰释药特征的脉冲药物载体的研究。
9)题目:板蓝根规范化种植种源研究基地合作项目。大庆市大同区。金额:75万。
获得的专利
ZL200610009931.3 朱大岭等
ZL200610010458.8 朱大岭等
XL200610010342.7 朱大岭等
201210084429.4 魏太明等
代表性科研成果
课题名称 /颁发机构/ 获奖类型
肺动脉高压发病的分子机制及治疗药物的研究/黑龙江省/省政府一等奖
肺动脉高压发病的分子机制及治疗药物的研究/黑龙江省/省政府医药卫生科技进步一等奖
15-LO/15-HETE在缺氧性肺动脉高压发病中的作用/教育部/自然科学奖二等奖
15-HETE致缺氧性肺动脉高压的分子和离子通道机理/黑龙江省/省政府二等奖
细胞色素P450系统在内外源物质代谢中的作用/黑龙江省/省政府二等奖
ERK1/2途径活化于15HETE收缩缺氧大鼠肺动脉的关系/黑龙江省/省政府三等奖
缺氧性肺高血压发病的分子和离子机理/黑龙江省/高校科学技术一等奖
氧化苦参碱对心肌缺血损伤大鼠的心肌保护作用研究/黑龙江省/自然科学技术成果二等奖
二氧化钛接枝的多孔聚苯乙烯-/马来酸酐纳米微球的制备/ 黑龙江省/自然科学技术成果一等奖
Voriconazole into PLGA nanoparticles/黑龙江省 /自然科学技术成果二等奖
中药红花的主要成分HSYA对肺动脉血管的作用/黑龙江省/自然科学技术成果一等奖
高速逆流法提取分离冬凌草甲素 /黑龙江省/自然科学技术成果二等奖
夹竹桃中的强心甾糖苷类生物活性物质研究/黑龙江省/自然科学技术成果三等奖
氧化苦参碱抗心律失常作用及机制研究/大庆市 /自然科学技术成果二等奖
接枝聚合法制备二氧化钛/聚苯乙烯-二乙烯苯纳米复合微球/大庆市/自然科学技术成果一等奖
抗真菌感染药物纳米给药系统的研究/大庆市/自然科学技术成果二等奖
SCI文章:
1. Yu L, Jin X, Cui N, Wu Y, Shi Z, Zhu D, Jiang C. Rosiglitazone selectively inhibits K(ATP) channels by acting on the K(IR) 6 subunit. Br J Pharmacol. 2012. IF=5.881
2. Guo L, Qiu Z, Wei L, Yu X, Gao X, Jiang S, Tian H, Zhu D. The MicroRNA-328 Regulates Hypoxic Pulmonary Hypertension by Targeting at Insulin Growth Factor 1 Receptor and L-Type Calcium Channel-α1C. Hypertension. 2012. IF=6.908
3. Yu L, Liu Y, Qiu Z, Liu S, Gao X, Zhu D. Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE.
J Recept Signal Transduct Res. 2012. IF=1.822
4. Zhu D, Ran Y. Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension. J Physiol Sci. 2012. IF=1.356
5. Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, Jiang C, Falck JR, Jacobs ER, Zhu D. A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. Pulm Pharmacol Ther. 2012. IF= 2.093
6. Nie X, Song S, Zhang L, Qiu Z, Shi S, Liu Y, Yao L, Zhu D. 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway. Prostaglandins Other Lipid Mediat. 2012. IF= 2.033
7. Ma C, Li Y, Ma J, Liu Y, Li Q, Niu S, Shen Z, Zhang L, Pan Z, Zhu D. Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension. Hypertension. 2011. IF=6.908
8. Liu Y, Wang R, Li J, Rao J, Li W, Falck JR, Manthati VL, Medhora M, Jacobs ER, Zhu D. Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs. Hypertens Res. 2011. IF= 2.353
9. Jiang J, Wang S, Wang Z, Ma J, Liu S, Li W, Zhu D. The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells. J Recept Signal Transduct Res. 2011. IF=1.822
10. Jingjing Rao, Jing Li, Yun Liu ,Ping Lu, Xiaojiao Sun, P. K. Sugumaran, Daling Zhu. The key role of PGC-1a in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure. Molecular and Cellular Biochemistry. 2012. IF= 2.168
11. Jun Ma, Lei Zhang, Weina Han, Tingting Shen, Cui Ma, Yun Liu, Xiaowei Nie, Mengmeng Liu, Yajuan Ran, and Daling Zhu. Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells. JLR Papers in Press. 2012. IF= 6.216
12 Yun Liu,Cui,Ma,Qianlong Zhang,Lei Yu,Jun Ma, Lei Zhang, Xuewei Hao, Fang Yuan, Lin Wang, Daling Zhu. the key role of transforming growth factor-beta receptor I and 15- lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells. The International Journal of Biochemistry & Cell Biology.2012. IF= 4.956
13. Yu L, Jin X, Cui N, Wu Y, Zhu D, Jiang C. Rosiglitazone selectively inhibits KATP channels by acting on the Kir6 subunit. Br J Pharmacol. 2012. IF= 4.99
14. Xin Jin, Lei Yu, Shuang Zhang, Yang Wu, Zhenda Shi, Xianfeng Chen, Xiaoli Zhang and Chun Jiang. S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. J Physiol. 2012. IF=4.38
15. Yu L, Jin X, Yang Y, Cui N, Jiang C. Rosiglitazone inhibits vascular K(ATP) channels and coronary vasodilation produced by isoproterenol. Br J Pharmacol. 2011. IF= 4.99
16. Yu L, Yun L, Zhaoping Q, Shulin Liu, Xu G, Daling Z. Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE. Journal of Receptors and Signal Transduction. 2012. IF=1.611
17. Wang Y, Yu L, Cui N, Zhu D, Jiang C. Differential sensitivities of the vascular KATP channel to various PPAR activators. Biochem Pharmacol. 2013. IF=4.65
18. Yang Y, Li S, Konduru AS, Zhang S, Trower TC, Shi W, Cui N, Yu L, Wang Y, Zhu D, Jiang C. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. Am J Physiol Cell Physiol. 2012. IF= 3.674
19. Liu Y, Ma C, Zhang Q, Yu L, Ma J, Zhang L, Hao X, Cao F, Wang L, Zhu D. The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells. Int J Biochem Cell Biol. 2012. IF=4.95
20. Cui N, Zhang X, Tadepalli JS, Yu L, Gai H, Petit J, Pamulapati RT, Jin X, Jiang C. Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons. J Neurophysiol. 2011. IF=4.00
21. Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, Jiang C, Falck JR, Jacobs ER, Zhu D: A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. Pulm Pharmacol Ther. 2012. IF=2.09
22. Jun Ma, Shujun Liang, Zhigang Wang, Lei Zhang, Jing Jiang, Lei Yu, Xiaodong Zheng, Daling Zhu. ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid mediated the pulmonary vascular remodeling induced by hypoxia in rat. Journal of Cellular Physiology. 2010. IF =3.87
23. Ikoba U, Peng HS, Li HC, Miller C, Yu CX, and Wang Q. Nanocarriers in Therapy of Infectious and Inflammatory Diseases. Nanoscale. 2015. IF=6.739
24. Peng HS, Wang C, Yu CX, and Wang Q. An Intestinal Trojan Horse for Gene Delivery. Nanoscale. 2015. IF=6.739
25. Wang Q, Cheng H, Peng HS, Zhou H, Li Peter Y, and Langer R. Non-genetic Engineering of Cells for Drug Delivery and Cell-based Therapy. Advanced drug delivery review. 2015. IF=12.707
26. Peng HS, Liu XP, Wang R, Jia F, Dong L, and Wang Q. Emerging Nanostructured Materials for Musculoskeletal Tissue Engineering. J Mater Chem B. 2014. IF=6.636
27. Sun SL, Guo L, Ren YC, Wang B, Li RH, Qi YS, Yu H, Chang ND, Li MH, and Peng HS. Anti-apoptosis effect of polysaccharide isolated from the seeds of Cuscuta chinensis Lam on cardiomyocytes in aging rats. Mol Biol Rep. 2014. IF=1.958
28. Zhen XE, Zong M, Gao SN, Cao YG, Jiang L, Sun SQ, Peng HS, Bai YH, Li S. Preparation and Characterization of a novel aspirin derivative with anti-thrombotic and gastric mucosal protection properties. Plos One. 2014. IF=3.534
29. Du D, Chang ND, Sun SL, Li MH, Yu H, Liu MF, Liu XY, Wang GT, Li HC, Liu XP, Geng SL, Wang Q, and Peng HS. The Role of Glucose Transporters in Distribution of Liposomes Modified with P-Aminophenyl - α-D-Mannopyranoside in Mice Brain. J Control. Release. 2014. IF=7.261
30. Liu MF, Li MH, Wang GT, Liu XY, Liu DM, Peng HS, and Wang Q. Heart-targeted nanoscale drug delivery systems. J Biomed. Nanotech. 2014. IF=7.578
31. Liu MF, Li MH, Sun SL, Li BX, Du D, Sun JL, Cao FY, Li HC, Jia F, Wang T, Chang ND, Yu H, Wang Q, and Peng HS. The use of antibody modified liposomes loaded with AMO-1 to deliver oligonucleotides to ischemic myocardium for arrhythmia therapy. Biomaterials. 2014. IF=8.312
32. Li MH, Yu H, Wang TF, Chang ND, Zhang JQ, Du D, Liu MF, Sun SL, Wang R, Tao HQ, Wang Q, and Peng HS. Tamoxifen Embedded in Lipid Bilayer Improved the Oncotarget of Liposomal Daunorubicin in vivo. J Mater Chem B. IF=6.636
33. Li MH, Deng HB, Peng HS, Wang Q. Functional Nanoparticles in Targeting Glioma Diagnosis and Therapies. J Nanosci Nanotech. 2014. IF=1.339
34. Niu J, Xing C, Yan C, Liu H, Cui Y, Peng H, Chen Y, Li D, Jiang C, Li N, Yang H. Lentivirus-mediated CD/TK fusion gene transfection neural stem cell therapy for C6 glioblastoma. Tumor Biol. 2013. IF=2.840
35. Hao ZF, Cui YX, Li MH, Du Dan, Liu MF, Tao HQ, Li S, Cao FY, Chen YL, Lei XH, Wang L, Zhu DL, Peng HS, Jiang CL. Liposomes Modified with P-Aminophenyl-α-D-Mannopyranoside: A Carrier for Targeting Cerebral Functional Regions in Mice. Eur J Pharm Biopharm. 2013. IF=4.245
36. Tao HQ, Li MH, Yu H, Liu MF, Du Dan, Sun SL, Yang HC, Wang YM, Ye W, Yang LZ, Zhu DL, Jiang CL, Peng HS. HP-β-CD-PLGA nanoparticles improve the penetration and bioavailability of puerarin and enhance the therapeutic effects on brain ischemia–reperfusion injury in rats. Naunyn-Schmiedeberg's. Arch Pharmacol. 2013. IF=2.360
37. Fa He, Yuhua Bai, Jing Wang, Jing Wei, Sen Li, Weili Yang and Chenghua Han. Isolation and Purification of Oridonin from the Whole Plant of Isodon rubescens by High-Speed Counter-Current Chromatography. Molecules. 2011. IF=2.095
38. Ming-Juan Chu, You-ZhiWang, Kiyoshi Itagaki, Hong-Xing Ma, Ping Xin, Xue-Gang Zhou, Guo-You Chen, Sen Li, Shi-Qin Sun. Identification of active compounds from Caesalpinia sappan L. extracts suppressing IL-6 production in RAW 264.7 cells by PLS. Journal of Ethnopharmacology. 2013. IF=2.939
39.Zhong-fei Hao, Yu-xia Cui, Ming-hui Li, Dan Du, Mei-fang Liu, Sen Li, Da-ling Zhu, Hai-sheng Peng, Chuan-lu Jiang. Liposomes modified with P-aminophenyl-a-D-mannopyranoside: A carrier for targeting cerebral functional regions in mice. European Journal of Pharmaceutics and Biopharmaceutic. IF=4.245
40、Yuhua Bai, Ping Lu, Chenghua Han, Chunyue Yu, Minggang Chen, Fa He, Lijun Wu. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery. Molecules. 2012. IF= 2.095
41、Yuhua Bai, Ming Zhao, Liming Bai, Ryo Hasegawa, Masayoshi Ando. The biological activities of cardenolide triglycosides from stems and twigs, and leaves of Nerium oleander. Journal of Wood Science. 2011. IF= 0.825
42、Ming Zhao, Liming Bai, Asami Toki, Ryo Hasegawa, Jun-ichi Sakai, Toshiaki Hasegawa, Tomokazu Mitsui, Yuhua Bai, Mariko Ando, Katsutoshi Hirose and Masayoshi Ando,The Structure of A New Cardenolide Diglycoside and the Biological Activities of Eleven Cardenolide Diglycosides from Nerium oleander. Chemical & Pharmaceutical Bulletin. 2011. IF = 1.375
43、Liming Bai, Ming Zhao, Asami Toki, Toshiaki Hasegawa, Jun-ichi Sakai, Xiao-yang Yang, Yuhua Bai, Hirotsugu Ogura, Tomokazu Mitsui and Takao Kataoka, et al. Polar cardenolide monoglycosides from stems and twigs of Nerium oleander and their biological activities. Journal of Wood Science. 2011. IF= 0.825
44、Liming Bai, Ming Zhao, Asami Toki, Jun-ichi Sakai, Xiao-yang Yang, Yuhua Bai. Three New Cardenolides from Methanol Extract of Stems and Twigs of Nerium oleander. Chemical & Pharmaceutical Bulletin. 2010. IF= 1.375
45、Liyan Wang, Liming Bai, Daiske Tokunaga, Yuusuke Watanabe, Toshiaki Hasegawa, Junichi Sakai, Wanxia Tang, Yuhua Bai, Katsutoshi Hirose, Takao Yamori, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando.The polar neutral and basic taxoids isolated from needles and twigs of taxus cuspidata and their biological activity. Journal of Wood Science. 2008. IF= 0.825
46、Hasegawa T,Bai J, Dai J, Bai L, Sakai J, Nishizawa S, Bai Y. et al.Synthesis and Structure-Activity Relationships of Taxuyunnaine C Derivatives as Multidrug Resistance Modulators in MDR Cancer Cells. Bioorganic & Medicinal Chemistry Letters. 2006. IF=2.331
47、Liyan Wang,Liming Bai,Daisuke Tokunaga,Yuusuke Watanabe,Jun-ichi Sakai,Wanxia Tang,Yuhua Bai, et al.Two New Taxoids from the Needles and Young Stems of Taxus cuspidata,Heterocycles. 2008. IF=0.908
48、Gao WY, Su XJ, Dong XY, Chen YL, Zhou CL, Xin P, Yu CH, Wei TM. Cycloartan-24-ene-1α,2α,3 β-triol, a cycloartane-type triterpenoid from the resinous exudates of Commiphora myrrha, induces apoptosis in human prostatic cancer PC-3 cells. Oncology Reports. 2015. IF=2.191
49、Gao WY, Dong XY, Xie N, Zhou CL, Fan YH, Chen GY, Wang YM, Wei TM, Zhu DL. Dehydroabietic acid isolated from Commiphora opobalsamum causes endothelium-dependent relaxation of pulmonary artery via PI3K/Akt-eNOS signaling pathway. Molecules. 2014. IF= 2.095
50、YingLi chen,ChunLan zhou,YuFa liu,YuMing liu,WeiYi feng,Sen li,GuoYou chen,TaiMing wei. Composition and potential anticancer activities of essential oils obtained from myrrh and frankincense. Oncology Letters. 2013. IF= 0.987
51、 Li Y, Li Q, Wang Z, Liang D, Liang S, Tang X, Guo L, Zhang R, Zhu D.15-HETE suppresses K+ channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells. Apoptosis. 2009. IF=3.614
52. Li Yumei, Kumazawa Toshihiko, Ishiguro Tsukasa, Kawakami Yuriko, Nishitani Hiromi, Matsumoto Yukiharu. Hypothyroidism caused by henobarbital affects patterns of estrous cyclicity in rats. Congenital Anomalies. 2011. IF=0.783
53. Li Zhang, Yumei Li, Minggang Chen, Xiaojie Su, Dan Yi, Ping Lu and Daling Zhu. 15-LO/15-HETE mediated vascular adventitia fibrosis via p38 MAPK-dependent TGF-β1. J Cell Physiol. 2013. IF=4.2
54. Zhang L, Li Y, Xu C, Li X, Zhu D, Zhang Y, Xing S, Wang H, Zhang Z, Shan H. Tanshinone IIA Improves miR-133 Expression Through MAPK ERK1/2 Pathway in Hypoxic Cardiac Myocytes. Cell Physiol Biochem. 2012. IF=3.55
55. Chen M, Liu Y, Yi D, Wei L, Li Y & Zhang L. Tanshinone IIA Promotes Pulmonary Artery Smooth Muscle Cell Apoptosis in Vitro by Inhibiting the JAK2/STAT3 Signaling Pathway. Cell Physiol Biochem. 2014. IF=3.55
56. Wang Z, Li Y, Leu C, Guo L, Zheng X, Zhu D. 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. Eur J Pharmacol. 2008. IF=2.684
57. Yumei Li, Scott Shi, Geremy Koumbadinga, and Edward O Brien. Extracellular Heat Shock Protein 27: a new modulator of atherosclerosis. Cellular and Molecular Life Sciences. IF=5.02