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刘肖莹

发布时间:2022-04-04 13:32:03  作者:本站编辑  来源:本站原创  浏览次数:

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刘肖莹女,199011月出生,中共党员,讲师,硕士毕业于哈尔滨医科大学。现主持科研课题共5项,参与国家自然基金面上项目、省级重点项目等5项。已发表论文24篇,其中SCI论文16篇,获黑龙江省省政府自然科学三等奖1项,黑龙江省医药卫生科学技术奖一等奖1项,市自然科学成果奖二等奖1项;申报专利8项,授权4项。参加《分子药剂学》、《群星闪药》在线课程2项,参编教材3部。主要承担《药剂学》、《制剂工程学》、《中药药剂学》、《药剂学实验》等课程。指导学生获得国家级大创立项2项,省级大创立项1项。指导学生获得第六届互联网+大赛国家级铜奖、第六届互联网+大赛省级金奖、第五届互联网+大赛省级金奖、黑龙江省全国移动互联创新大赛一等奖等10项。

 

主持和参加科研项目

1. 哈尔滨医科大学大庆校区成果转化培育项目,CXZX-ZXKT03,双修饰纳米颗粒的构建及治疗心源性脑卒中的研究,2021.4-2024.4 4万元,在研,主持

2.伍连德青年科学研究基金,双修饰纳米颗粒的构建及大鼠体内分布的研究,2020/10-2023/1010万元,在研,主持

3.珠海市人民医院培育项目,新型脑靶向性脂质体治疗小鼠脑缺血模型的分布调控及机制研究,2020/02-2023/028万元,在研,主持

4.哈尔滨医科大学创新科学研究基金,miR-21纳米复合体对急性心肌梗死的治疗研究,2018/11-2020/104.8万元,已结题,主持

5.哈医大大庆校区校内科研基金,2018XN-22,心肌靶向纳米复合体的构建及相关作用机制的研究,2018/08-2021/083万元,已结题,主持

6.大庆市指导性科技计划项目, zdy-2016-083,双靶脂质体体内分布研究,2016/12-2018/04,已结题,主持

7.国家自然基金面上项目,81671814,糖/抗体/肽靶向纳米载体的表面()物质基础对缺血心肌miR-1/MMP9/Glut1摄取调控机制,2017/01-2018/1225万元,已结题,参加

8.黑龙江省自然基金重点项目,ZD2016013,微环境响应性心靶向纳米复合体的构建与疗效研究,2016/07-2019/0720万元,已结题,参加

9.黑龙江省普通本科高等学校青年创新人才培养计划课题,UNPYSCT-2015036,双靶修饰脂质体治疗脑胶质瘤的研究,2016/01-2018/1210万元,已结题,参与

 10.企业委托项目,抗感泡腾片的放大工艺研究,2018/9-2019/3,45万,已结题,参加

 

发表文章

1. Bo Yang, Jiaqi Jiang, Lei Jiang, Peiyu Zheng, Fuling Wang, Yang Zhou, Zhong Chen, Minghui Li, Mingming Lian, Shukun Tang, Xiaoying Liu*, Haisheng Peng*, and Qun Wang*. Chitosan mediated solid lipid nanoparticles for enhanced liver delivery of zedoary turmeric oil in vivo. International Journal of Biological Macromolecules. 2020, 149(15): 108-115.

2. Xiaoying Liu, Shukun Tang, Yuncui Liu, DandanHu, Changmei Zhang, Wenyuan Zhang, Yanqun Chai, Xuefeng Tang, Lei Jiang,Chen Gong, Haisheng Peng*, Minghui Li*. Targeting Regulation of Dually Modified Liposomes by Polyethylene Glycol Length of Vesicle Surface. Journal of Biomedical Nanotechnology. 2019; 12(15): 2413-2427

3. Haisheng Peng, Xiaoying Liu, Guangtian Wang, Minghui Li, Kaitlin M. Bratlie, Eric Cochran, Qun Wang. Advances of Polymeric Multifunctional Nanomaterials in Theranostics. J. Mater. Chem. B .2015. 3,6856-6870

4. Wenhua Li, Zhong Chen, Xiaoying Liu, Mingming Lian, Haisheng Peng*, Changmei Zhang*. Design and evaluation of glutathione responsive glycosylated camptothecin nanosupramolecular prodrug. Drug Delivery. 2021;28(1):1903-1914.

5. Wenyuan Zhang, Man Zhao, Yali Gao, Xu Cheng, Xiaoying Liu , Shukun Tang ,Yanbo Peng , Na Wang , Dandan Hu , Haisheng Peng *, Jinqiu Zhang *, Qun Wang*. Biomimetic erythrocytes engineered drug delivery for cancer therapy. Chemical Engineering Journal. 2021

6. Liwang Shi , Jinqiu Zhang , Man Zhao , Shukun Tang , Xu Cheng , Wenyuan Zhang , Wenhua Li, Xiaoying Liu, Haisheng Peng* , Qun Wang* . Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery. Nanoscale. 2021;13(24):10748-10764.

7. Minghui Li, Xuefeng Tang, Xiaoying Liu, Xinyu Cui, Mingming Lian, Man Zhao, Haisheng Peng*, Xiaojun Han*. Targeted miR-21 loaded liposomes for acute myocardial infarction. Journal of Materials Chemistry B. 2020

8. Wenhua Li, Xiaoying Liu, Xu Cheng, Wenyuan Zhang, Chen Gong, Chuya Gao, Haisheng Peng, Bo Yang, Shukun Tang, Haiquan Tao. Effect of Malt-PEG-Abz@RSL3 micelles on HepG2 cells based on NADPH depletion and GPX4 inhibition in ferroptosis. J Drug Target. 2021 Aug 11:1-11. doi: 10.1080/1061186X.2021.1953511. Epub ahead of print. PMID: 34236257.

9.Changmei Zhang, Zhong Chen, Wenhua LiXiaoying Liu, Shukun Tang, Lei Jiang, Minghui Li, Haisheng Peng *, and Mingming Lian*. Influences of Different Sugar Ligands on Targeted Delivery of Liposomes. Journal of Drug Targeting. 2020; 28(7-8): 789-801

10. Chunyue Wang, Zhong Chen, Xuefeng Tang, Xiaoying Liu, Na Wang, Wenhua Li*, Ting Liu*. Influences of galactose ligand on the uptake of TADF liposomes by HepG2 cells. Photodiagnosis and Photodynamic Therapy 2020.

11. Na Wang, Wenyuan Zhang, Dandan Hu, Lei Jiang, Xiaoying Liu, Shukun Tang,

Xuegang Zhou, Ting Liu, Xuefeng Tang, Yanqun Chai, Minghui Li, Haisheng Peng*,

Zhimin Du*. ‘Prodrug-like’ acetylmannosamine modified liposomes loaded with arsenic trioxide for the treatment of orthotopic glioma in mice. Journal of Pharmaceutical Sciences. 2020 ;109(9):2861-2873

12. Lei Jiang, Jiahe Wang, Jiaqi Jiang, Changmei Zhang, Man Zhao, Zhong Chen, Na Wang, Dandan Hu, Xiaoying Liu, Haisheng Peng*, Mingming Lian*. Sonodynamic Therapy in Atherosclerosis by Curcumin Nanosuspensions: Preparation design, Efficacy Evaluation, and Mechanisms Analysis. European Journal of Pharmaceutics and Biopharmaceutics. 2020,146: 101-110.

13. Meifang Liu, Minghui Li, Guangtian Wang, Xiaoying Liu. Daming Liu, Qun Wang, Haisheng Peng. Heart-Targeted Nanoscale Drug Delivery Systems. Biomedical Nanotechnology. 2014.10, 2038-2062.

14. Dan Du, Naidan Chang, Souli Sun, Minghui Li, Hui Yu, Meifang Liu, Xiaoying Liu, Guangtian Wang, Haichun Li, Xunpei Liu, Shilong Geng, Qun Wang, Haisheng Peng. The role of glucose transporters in the distribution of p-aminophenyl-α-D- mannopyranoside modified liposomes within mice brain. Journal of controlled release, 2014, 182: 99-110.

15. Daming Liu, Shukun Tang, Guangtian Wang, Minghui Li, Xiaoying Liu, Haiquan Tao, Yachao Ren, Haisheng Peng, Mingming Lian, and Chuanlu Jiang. The Influences of Dynamic Transport of GLUT1 on the Distribution of Mannosylated Liposomes in Transient Ischemia Reperfusion Mice Brain. J. Biomed. Nanotech. 2017, 13: 638-654.

16. Jingyan Cao, Ran Wang, Ning Gao, Minghui Li, Xuyu Tian, Weili Yang, Ying Ruan, Chunlan Zhou, Guangtian Wang, Xiaoying Liu, Shukun Tang, Yan Yu, Ying Liu, Guangyu Sun, Haisheng Peng*, and Qun Wang*. A7RC peptide modified paclitaxel liposomes dually target breast cancer. Biomaterials Science. 2015, 3: 1545- 1554.

 

 获奖情况

1. 黑龙江省省政府自然科学三等奖,心脑及肿瘤缺血组织靶向制剂设计及机理研究,2019

2. 黑龙江省医药卫生科学技术一等奖,心脑及肿瘤缺血组织靶向制剂设计及机理研究,2019

3. 用于治疗疾病的多功能纳米聚合物的研究,大庆市科技局,大庆市第二十六届自然科学技术学术成果奖,二等奖,2017

 

专利

1.一种心脑双靶向脂质体及其制备方法和应用。批准号:ZL201810299429.3

2.一种抗心肌肌钙蛋白抗体修饰并载有miR-21的脂质体及其制备方法和应用。批准号:ZL20181098620.X

3.一种乙酰化糖酯-聚乙二醇-磷脂酰乙醇胺共轭物及其制备方法与应用。批准号: ZL201810301839.7

4.-聚乙二醇-DSPE偶联化合物及其制备方法与应用。批准号:ZL 201811062535.6

5.一系列热激活延迟荧光(TADF)纳米探针制备及其在生物成像中的应用。申请号:201811325113.3

6.聚乙二醇修饰的人胸腺素β4二串体蛋白及其制备方法和应用。申请号:201911001508.2

7.一种邻细胞间相互作用的研究方法。申请号:201910886668.3

8.一种糖基联合细胞穿透肽修饰的脑靶向纳米脂质体及其制备方法与应用。申请号:202010121215.4

 

主持和参加教学项目

1. 哈尔滨医科大学校内教研课题,专创融合视域下中药学专业人才培养模式的研究,2021.3-2023.12,在研,主持人

2. 哈尔滨医科大学思想政治教育工作科研基金立项课题资助特殊学情思政教育干预研究 2018.03-2019.03,结题,参与

3. 国家级大创立项,合成磷脂,2020/1-2021/11万元,在研,指导教师

4. 国家级大创立项,元气满满即食人参,2021/1-2022/11万元,在研,第一指导教师

5. 省级大创立项,蓝莓山药咀嚼片,2020/1-2021/10.5万元,在研,指导教师


 

教育经历

2013/09-2016/06,哈尔滨医科大学,大庆校区药学院,硕士,导师:彭海生

2009/09-2013/06,哈尔滨医科大学,大庆校区药学院,学士

 

研究工作经历

2016.7 - 至今,哈医大大庆校区 药学院 药剂教研室 助教

2018.10 - 至今,哈医大大庆校区 药学院 药剂教研室 秘书

 


地址:黑龙江省大庆市高新区新阳路 39 邮政编码:163319
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版权所有:哈尔滨医科大学大庆校区
地址:黑龙江省大庆市高新区新阳路39
黑ICP备2021002235号-1