于磊

发布时间：2022-04-26 08:59:08 作者：本站编辑来源：本站原创浏览次数：

于磊，女，1981年10月生，博士，副教授，硕士生导师，药学院副院长。2004年毕业于沈阳药科大学药学专业，获学士学位；2012年毕业于哈尔滨医科大学药理学专业，获博士学位。2009年进修于美国佐治亚州立大学，主要从事离子通道在心血管张力调节机制中的作用等相关药理学，以及生物制药学方向的研究工作。

主持国家自然科学基金一项，省教育厅课题一项，省卫生厅课题一项。2008年获黑龙江省科学与技术进步二等奖及省教育厅科学与技术进步一等奖，2009年获黑龙江省科学与技术进步二等奖，2011年获黑龙江省高校科学技术一等奖及教育厅高等学校科学研究优秀成果二等奖一项。共发表SCI收录文章11篇。，

发表文章：

1. Yu L, Jin X, Cui N, Wu Y, Shi Z, Zhu D, Jiang C. Rosiglitazone selectively inhibits KATP channels by acting on the Kir6 subunit. Br J Pharmacol. 2012 Mar 6. doi: 10.1111/j.1476-5381.2012.01934.x.

2. Xin Jin*, Lei Yu* Shuang Zhang, Yang Wu, Zhenda Shi, Xianfeng Chen1, Yang Yang2, Xiaoli Zhang3 and Chun Jiang,* S-Glutathionylation underscores the modulation of the heteromeric Kir4.1-Kir5.1 channel in oxidative stress. J Physiol. 2012 Nov 1;590(Pt 21):5335-48.

3. Yu L*, Jin X*, Yang Y, Cui N, Jiang C. Rosiglitazone inhibits vascular K(ATP) channels and coronary vasodilation produced by isoproterenol. Br J Pharmacol. 2011 Dec;164(8):2064-72. doi: 10.1111/j.1476-5381.2011.01539.x. (IF 4.4)

4. Yu L*, Yun L*, Zhaoping Q, Shulin Liu, Xu G, Daling Z. Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE. Journal of Receptors and Signal Transduction. 2012 Apr;32(2):87-95. Epub 2012 Mar 6.

5. Wang Y, Yu L, Cui N, Jin X, Zhu D, Jiang C. Differential sensitivities of the vascular KATP channel to various PPAR activators Biochem Pharmacol. 2013 May 15;85(10):1495-503.

6. Yang Y, Li S, Konduru AS, Zhang S, Trower TC, Shi W, Cui N, Yu L, Wang Y, Zhu D, Jiang C. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. Am J Physiol Cell Physiol. 2012 Nov 15;303(10):C1045-54.

7. Liu Y, Ma C, Zhang Q, Yu L, Ma J, Zhang L, Hao X, Cao F, Wang L, Zhu D. The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells. Int J Biochem Cell Biol. 2012 Jul;44(7):1184-202. Epub 2012 Apr 19. (IF 4.95)

8. Cui N, Zhang X, Tadepalli JS, Yu L, Gai H, Petit J, Pamulapati RT, Jin X, Jiang C. Involvement of TRP channels in the CO₂ chemosensitivity of locus coeruleus neurons. J Neurophysiol. 2011 Jun;105(6):2791-801. Epub 2011 Mar 23. (IF 4.00)

9. Liu Y, Zhang J, Yu L, Cao F, Rao J, Li J, Jiang C, Falck JR, Jacobs ER, Zhu D: A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels. Pulm Pharmacol Ther. 2012 Feb;25(1):69-76. Epub 2011 Dec 3.(IF 2.09)

10. Jun Ma, Shujun Liang, Zhigang Wang, Lei Zhang, Jing Jiang, Jinhua Zheng, Lei Yu, Xiaodong Zheng, Ruifang Wang, Daling Zhu: ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat. Journal of Cellular Physiology. 2010 222(1): 82-94. (IF 3.87)

11. Wu ZH, Tang XB, Wang ZG, Ji HY, Yu L, Liu HW, Zhu DL : Preparation and characterization of monoclonal antibody against human carboxylesterases-II. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Feb;23(2):148-51.