白玉华
白玉华,女 ,1970年2月出生,博士,教授,硕士生导师 。留日、澳归国学者;美国化学会会员。主持参加国家自然基金委与日本科学振兴机构联合资助项目1项;黑龙江省自然科学基金(留学归国人员与及海外合作)项目1项;黑龙江省卫生厅项目1项;黑龙江省教育厅基金项目1项;黑龙江省中医药管理局中青年公关项目1项;黑龙江省高等教育学会“十二五”教育科学研究规划课题1项。近几年在国内外学术期刊共发表论文30篇,其中国外学术期刊发表SCI收录文章25篇;撰写论著中文2部;参加编写外文论著2部;建设精品课程1门。连续获大庆市第二十二届、二十三届、二十四届、二十六届自然科学技术学术成果奖励, 黑龙江省自然科学技术学术成果奖1项(1等奖2项);获大庆市三八红旗手、哈尔滨医科大学巾帼模范称号、哈尔滨医科大学优秀教研室主任、优秀教师等荣誉称号。
主持课题
1.2009年获黑龙江省自然科学基金(留学归国及海外合作基金)1项,题目为东北苍耳抗癌活性成分研究,获批资金5万元。 课题号№LC2009C12.
2.2011年关于创建中药学专业创新型人才培养模式的探讨
3.2013年黑龙江省教育厅课题,HSYA降低肺动脉高压作用机制的研究。编号12541409 2014.01-2016.12
4.黑龙江省中医局中青年攻关课题,中药红花抗肺动脉高压作用及其机制研究。编号 IQG-050,2014.07-2017.12。
发表论文
1.Yan, Qiao; Bolte, Benoit; Bai, Yuhua; Banwell, Martin; Willis, Anthony; Carr, Paul. Studies on the Photochemical Rearrangements of Enantiomerically Pure, Polysubstituted and Variously Annulated Bicyclo[2.2.2]octenones.Journal of Organic Chemistry. (影响因子4.8489)
2.Chenghua Han, Jing Qi, Sainan Gao, Chunxiang Li, Ying Ma, Jing Wang, Yuhua Bai, Xiaodong Zheng.Vasodilation effect of volatile oil from Allium macrostemon Bunge are mediated by PKA/NO pathway and its constituent dimethyl disulfide in isolated rat pulmonary arterials. Fytoterapia ,2017,120,52-57. (影响因子2.408)
3.Lei Li,PengdaDong, CongjiaHou, FangyuanCao, ShouliSun, FaHe, YanpingSong,Sen Li, Yuhua Bai*,Daling Zhu. Hydroxysafflor yellowA(HSYA) attenuates hypoxic pulmonaryarterial remodelling andreverses right ventricular hypertrophyinrats, Journal of Ethnopharmacology. 2016, 186:224-233. (影响因子3.035)
4.He F, Wang M, Gao M, Zhao M, Bai yuhua(通讯),Zhao C. Chemical composition and biological activities of Gerbera anandria. Molecules, 2014 :19(4):4046-57. (影响因子3.386)
5.MingZong,ShanLin,Yan-PingSong,Ze-YuWang,Xiao-LiangMa,Wei-HuaQiu,Yu-HuaBai,LeiLi,SenLi.Anti-cancer activity and potential mechanism of a novel aspirin derivative. European Journal of Pharmacology Volume 791, 15 November 2016, 137-146. (影响因子2.896)
6. Xi-E Zhen, Ming Zong, Sai-Nan Gao, Yong-Gang Cao, Lei Jiang, Shu-Xin Chen, Kuan Wang, Shi-Qin Sun, Hai-Sheng Peng, Yu-Hua Bai, and Sen Li* Preparation and Characterization of a Novel Aspirin Derivative with Anti-Thrombotic and Gastric Mucosal Protection Properties. PLoS One. 2014; 9(6): e98513. (影响因子2.806).
7.Yuhua Bai, Ping Lu, Chenghua Han, Chunyue Yu, Minggang Chen, Fa He, Dan Yi, Lijun Wu. Hydroxysafflor Yellow A (HSYA) from Flowers of Carthamus tinctorius L. and Its Vasodilatation Effects on Pulmonary Artery, Molecules 2012, 17, 14918-14927. (SCI) 获大庆市第二十四届自然科学技术成果一等奖;黑龙江省第十三届自然科学技术成果一等奖。(影响因子2.861)
8.Fa He , Yuhua Bai* , Jing Wang , Jing Wei, ChunYue Yu, Sen Li, Weili Yang and Chenghua Han. Isolation and Purification of Oridonin from the Whole Plant of Isodon rubescens by High-Speed Counter-Current Chromatography,Molecules 2011, 16(9), 7949-7957. (SCI)获大庆市第二十四届自然科学技术成果二等奖. 黑龙江省第十三届自然科学技术成果二等奖。(影响因子2.861)
9.Yuhua Bai, Ming Zhao; Liming Bai; Ryo Hasegawa; Jun-ichi Sakai; Toshiaki Hasegawa; Tomokazu Mitsui; Hirotsugu Ogra; Takao Kataoka; Katsutoshi Hirose; Masayoshi Ando .The biological activities of cardenolide triglycosides from stems and twigs, and leaves of Nerium oleander, Journal of Wood Science.2011, 57(1) : 56-65.(SCI)获大庆市第二十三届自然科学技术成果二等奖; 黑龙江省第十二届自然科学技术成果三等奖。(影响因子1.165)
10.Ming Zhao, Liming Bai, Asami Toki, Ryo Hasegawa, Jun-ichi Sakai, Toshiaki Hasegawa, Tomokazu Mitsui, Hirotsugu Ogura, Takao Kataoka, Yuhua Bai, Mariko Ando, Katsutoshi Hirose and Masayoshi Ando,The Structure of A New Cardenolide Diglycoside and the Biological Activities of Eleven Cardenolide Diglycosides from Nerium oleander,Chemical & Pharmaceutical Bulletin,2011,59(3):371-7(SCI)(影响因子1.133)
11.Liming Bai, Ming Zhao, Asami Toki, Toshiaki Hasegawa, Jun-ichi Sakai, Xiao-yang Yang, Yuhua Bai, Hirotsugu Ogura, Tomokazu Mitsui and Takao Kataoka, et al. Polar cardenolide monoglycosides from stems and twigs of Nerium oleander and their biological activities, Journal of Wood Science. 2011, 57(1) :47-55.(SCI)(影响因子1.165)
12.LI Sen, WANG Kuan, CHANG Kue-Chieh Alan, ZONG Ming,, WANG Jing,,CAO YongGang, BAI YuHua, WEI TaiMing & ZHANG ZhiRen.Preparation and evaluation of nano-hydroxyapatite poly(styrene-divinylbenzene) porous microsphere for aspirin carrier., SCIENCE CHINA Chemistry 2012,55(6)1134-1139. (影响因子4.132)
13.Liming Bai, Ming Zhao, Asami Toki, Jun-ichi Sakai, Xiao-yang Yang, Yuhua Bai, Mariko ANDO,f Katsutoshi HIROSE,g and Masayoshi ANDO. Three New Cardenolides from Methanol Extract of Stems and Twigs of Nerium oleander , Chemical & Pharmaceutical Bulletin ,2010,58(8):1088-1092(SCI)(影响因子1.133)
14.LIMING BAI, TOSHIAKI HASEGAWA, JIAO BA,MUTUMI KITABATAKE, JINLAN WANG, JUNICHI MATUBARA, JUN-ICHI SAKA,JUNGUI DAI, SHUJUN ZHANG, WANXIA TANG, LIYAN WANG, YUHUA BAI et al., Synthesis and Structure-ActivityRelationships of Some Taxoids as Multidrug Resistance Modulator in MDR Cancer Cells, 收编于国际专著Compendium of Bioactive Natural Products,Studium Press LLC, USA,2009-10.
15.Liming Bai, Liyan Wang, Liwei Fu, Ming Zhao, Shujun Zhang,,Saori Kakuta, Junichi Sakai, Wanxia Tang, Yuhua Bai et al., Oleanane-, ursane-, lupane-, and taraxasterane-type pentacyclic triterpenes isolated from the medicinal plants Nerium oleander, Ixeris chinensis, Sonchus oleraceus and Phytolacca americana. Cytotoxicity studies on human cancer cell lines, and MDR cancer reversal and anti-inflammatory activities, 收编于国际专著Pentacyclic Triterpene as a promising Agents in Cance, NOVA SCIENCE PUBULISHER INC. Hauppauge, NY, 2009-10.
16.Liyan Wang, Liming Bai, Daiske Tokunaga, Yuusuke Watanabe, Toshiaki Hasegawa, Junichi Sakai, Wanxia Tang, Yuhua Bai, Katsutoshi Hirose, Takao Yamori, Akihiro Tomida, Takashi Tsuruo, Masayoshi Ando.The polar neutral and basic taxoids isolated from needles and twigs of taxus cuspidata and their biological activity, Journal of Wood Science 2008, 54 (5), 390-401(SCI)(影响因子1.165)
17.Hasegawa T.,Bai J., Dai J., Bai L., Sakai J., Nishizawa S.,Bai Y. et al.Synthesis and Structure-Activity Relationships of Taxuyunnaine C Derivatives as Multidrug Resistance Modulators in MDR Cancer Cells,Bioorganic & Medicinal Chemistry Letters. 2006,17,(13):3722-3728.(SCI)(影响因子2.454)
18.Liyan Wang,Liming Bai,Daisuke Tokunaga,Yuusuke Watanabe,Jun-ichi Sakai,Wanxia Tang,Yuhua Bai.et al.Two New Taxoids from the Needles and Young Stems of Taxus cuspidata,HETEROCYCLES,2008,75,(4):911-917(SCI)(影响因子0.805)
19.Liyan Wang, Liming Bai,Toshiaki Hasegawa,Xiaoyang Yang,Yuhua Bai et al. Bioactive Triterpene Saponins from the roots of Phytolacca Americana . JOURNAL OF NATURAL PRODUTS.2008 ,71,(1):35-40(SCI)(影响因子2.454)
20.Ming Zhao, Liming Bai, Asami Toki,Ryo Hasegawa,Yuhua Bai et al. Bioactive Cardenolides from the stems and Twigs of Nerium oleander, JOURNAL OF NATURAL PRODUTS,2007,70( 7):1098-1103(SCI)(影响因子3.281)
21.Liyan Wang, Ming Zhao, Liming Bai, Asami Toki, Toshiaki Hasegawa, Midori Kikuchi, Mariko Abe, Jun-ichi Sakai, Ryo Hasegawa, Yuhua Bai, Tomokazu Mitsui, Hirotsugu Ogura, Takao Kataoka, Seiko Oka, Hiroko Tsushima, Miwa Kiuchi, Katsutoshi Hirose, Akihiro Tomida, Takashi Tsuruo, and Masayoshi Ando, Bioactive Cardenolides from the Stems and Twigs of Nerium Oleander,The 4th International Symposium on Advanced Materials in Asia-Pacific Rim,2007 (国际会议)
22.Shujun Zhang,Ming Zhao,Liming Bai, Toshiaki Hasagawa,Yuhua Bai et al. Bioactive Guaianolides from Siyekucai (Iexeris chinensis),JOURNAL OF NATURAL PRODUTS, 2006,69(10):1425-1428(SCI)(影响因子3.281)
23.白玉华,孙颖,于春月等.榛花挥发油化学成分.《药学与临床研究》,2010,18(3):265-266(国家核心期刊)
24.白玉华,王晶,孙颖等.冬凌草挥发油的GC-MS分析.《药学与临床研究》2009(5):370-372(国家核心期刊)
25.白玉华,安東正義.日本苦苣菜的化学成分 .《中国药科大学学报》2008(39)279-281,获大庆市第二十二届自然科学技术成果3等奖(国家核心期刊)
26.白玉华,于辉,孙世芹等.日本苦苣菜化学成分研究 《药学与临床研究》2008(6):444-446(国家核心期刊)
27.白玉华,安東正義,张维冰.日本苦苣菜Sonchus oleraceus L.的化学成分研究,齐齐哈尔大学学报, 2007,23(1):1-3.(国家核心期刊)
28.仪 丹, 侯丛佳,文学方,陈明刚,李磊等。去甲肾上腺素转运体的研究进展。现代生物医学进展,2014, 2794-2796.
29.韩成花, 高赛男, 白玉华, 马莹, 李春香. 薤白炮制前后鳞茎和叶挥发油的气相色谱-质谱联用分析。《时珍国医国药》2017年 第1期 111-113页。
主要奖项
1.2009年获大庆市第二十二届自然科学技术学术成果三等奖
2.2010年获大庆市三八红旗手荣誉称号
3.2011年获哈尔滨医科大学巾帼模范荣誉称号
4.2011年获哈尔滨医科大学优秀教研室主任荣誉称号
5.2011年获大庆市第二十三届自然科学技术学术成果二等奖
6.2011年获黑龙江省自然科学技术成果三等奖1项
7.2013年获大庆市第二十四届自然科学技术学术成果一等奖
8.2013年获大庆市第二十四届自然科学技术学术成果二等奖
9.2013年获黑龙江省自然科学技术成果一等奖1项
10.2013年获黑龙江省自然科学技术成果二等奖1项
11.2013年获哈尔滨医科大学优秀教师称号
发明专利
1.一种羟基红花黄色素A冻干粉针剂的制备方法及其产品,专利号2015100280717
2.羟基红花黄色素A在制备治疗缺氧性肺动脉高压的保健药物或功能食品中的用途,专利号2015100280596
教育经历
2012.09-2015.06 哈尔滨医科大学 药物化学 医学博士 导师 吴立军
2004.09-2007.03 齐齐哈尔大学 分析化学 硕士 导师 张维兵
2005.10-2006.10 日本新潟大学 天然产物化学 特别研究学生 导师 Masayoshi Ando
1987.09-1991.07 佳木斯医学院 化学制药
研究工作经历
2017.11-2018.11 澳大利亚 University of Tasmania,博士后
2014.07-2015.10 澳大利亚Australian National University, 高级访问学者
2005.10-2006.10 日本 Niigata University, 特别研究生
2007.07-至今 哈尔滨医科大学大庆校区 天然药物化学教研室主任